Wong Chui Fann, M. Sc.

Nanyang Technological University

School of Biological Sciences
60 Nanyang Drive
Singapore 637551

Email: S160024@e.ntu.edu.sg

FYP Thesis:

Novel insights into the N-terminus of Mycobacterium tuberculosis Alkylhydroperoxide Reductase subunit C. Degree in 2016

Master Thesis:

Mechanistic, enzymatic and structural insights into M.tuberculosis Alkyl-hydroperoxide reductase subunit C, a key enzyme of the mycobacterial antioxidant defense system as well as its interaction with its reducing partner, Thioredoxin C. Degree in 2017

PhD Thesis:

The mycobacterial F-ATP synthase subunit a, important subunit in catalysis and regulation. Start date Aug 2018

Publications:

1. Wong, C.F., Shin, J., Manimekalai, M.S.S., Saw, W.G., Zhan, Y., Bhushan, S. Kumar, A., Ragunathan, P. and Grüber, G.* (2017) The uniqueness of AhpC of the mycobacterial antioxidant defense system and its interaction with its reducing partner Thioredoxin-C. Sci. Rep. 7, 5159

2. Kamariah, N., Ragunathan, P., Shin, J., Saw, W.-G., Wong, C.F., Dick, T., and Grüber, G.* (2020) Unique structural and mechanistic properties of mycobacterial F-ATP synthases: Implications for drug design. Prog. Biophys. Mol. Biol. 152, 64-73

3. Saw, W.-G., Wong, C.-F., Dick, T., Grüber, G.* (2020) Overexpression, purification, enzymatic and microscopic characterization of recombinant mycobacterial F-ATP synthase. Biochem. Biophys. Res. Comm. 522, 374-380

4. Wong, C.-F., and Grüber, G.* (2020) The unique C-terminal extension of mycobacterial F-ATP synthase subunit α is the major contributor to its latent ATP hydrolysis activity. Antimicrob. Agents and Chemother. 64, e01568-20

5. Wong, C.-F., Lau, A.-M., Harikishore, A., Saw, W.-G., Shin J., Ragunathan, P., Bhushan, S., Ngan, S. F. C., Sze, S. K., Bates, R.W., Dick, T., and Grüber, G.* (2021) A systematic assessment of mycobacterial F1-ATPase subunit ε’s role in latent ATPase hydrolysis. FEBS J. 288, 818-836

6. Harikishore, A., Wong, C.-F., Ragunathan, P., Litty, D., Müller, V., and Grüber, G.* (2021) Targeting mycobacterial F-ATP synthase C-terminal α subunit interaction motif on rotary subunit γ. Antibiotics 10, 1456

7. Shin, J., Harikishore, A., Wong, C.-F., Ragunathan, P., Dick, T., and Grüber, G.* (2022) Atomic solution structure of Mycobacterium abscessus F-ATP synthase subunit ε and identification of Ep1MabF1 as a targeted inhibitor. FEBS J. in press