Dr. Arvind Kumar, PhD

Case Western Reserve University

School of Medicine
Cleveland, USA

PhD Thesis:

Structural and mechanistic insights into Mycothiol disulfide reductase, Mycoredoxin-1 and peroxiredoxin alkyl hydroperoxide subunit E of Mycobacterium tuberculosis. Degree in 2017

Publications:

1. Arvind, K., Anand Solomon, K., and Rajan, S. S. (2013) QSAR studies of tetranortriterpenoid: an analysis through CoMFA and CPSA parameters. Lett. Drug. Des. Discov. 10, 427-436

2. Arvind, K., Anand Solomon, K., and Rajan, S. S. (2013) QSAR studies on Diclofenac analogues as potent Cyclooxygenase inhibitors using CoMFA and CoMSIA. Med. Chem. Res. 23, 1789-1796

3. Kumar, A., Balakrishna, A. M.¹, Nartey, W.¹, Manimekalai, M. S. S., and Grüber, G. (2016) Redox chemistry of Mycobacterium tuberculosis alkylhydroperoxide reductase E (AhpE): Structural and mechanistic insight into a mycoredoxin-1 independent reductive pathway of AhpE via mycothiol. Free Rad. Biol. Med. 97, 588-601

4. Kumar, A., Nartey, W., Shin, J., Manimekalai, M. S. S., and Grüber, G. (2017) Structural and mechanistic insights into Mycothiol Disulphide Reductase and the Mycoredoxin-1-alkylhydroperoxide reductase E assembly of Mycobacterium tuberculosis. Biochim. Biophys. Acta-General Subject 1861, 2354-2366

5. Wong, C.F., Shin, J., Manimekalai, M.S.S., Saw, W.G., Zhan, Y., Bhushan, S. Kumar, A., Ragunathan, P. and Grüber, G.* (2017) The uniqueness of AhpC of the mycobacterial antioxidant defense system and its interaction with its reducing partner Thioredoxin-C. Sci. Rep. 7, 5159

6. Kumar, A., Manimekalai, M.S.S., and Grüber, G.* (2018) Substrate-induced structural alterations of Mycobacterial mycothiol disulphide reductase and critical residues involved. FEBS Lett. 592, 568-585