Assistant Professor Sandip Basak, PhD

Nanyang Technological University 

NTU Institute of Structural Biology

Experimental Medicine Building (EMB)

59 Nanyang Drive,

Singapore 636921.

PhD Thesis:

Structural and mechanistic insight into the rotating subunit F of vacuolar ATPase.

Publications:

1. Basak, S., Gayen, S., Thaker, Y. R., Manimekalai, M. S. S., Roessle, M., Hunke, C., and Grüber, G. (2011) Solution structure of subunit F (Vma7p) of the eukaryotic V1VO ATPase from Saccharomyces cerevisiae derived from SAXS and NMR spectroscopy. Biochim. Biophys. Acta-Biomembranes 1808, 360-368

2. Basak, S., Gayen, S., Ramalingam, J., Grüber, A., Preiser, R. P., and Grüber, G. (2011) NMR solution structure of NBD94483-502 of the nucleotide binding domain of the Plasmodium yoelii reticulocyte binding protein Py235. FEMS Microbiol. Letters 318, 152-158

3. Pattnaik, G., Sinha, B., Mukherjee, B., Ghosh, S., Basak, S., Mondal, S., and Bera, T. (2012) Submicron-size biodegradable polymer-based didanosine particles for treating HIV at early stage: an in vitro study. J. Microencapsul. 29, 666-676

4. Basak, S., Balakrishna, A. M., Manimekalai, M. S. S., and Grüber, G. (2012) Crystallization and preliminary X-ray crystallographic analysis of subunit F, F1-94, an essential coupling subunit of the eukaryotic V1VO ATPase from Saccharomyces cerevisiae. Acta Cryst. F68, 1055-1059

5. Biuković, G., Basak, S., Manimekalai, M. S. S., Rishikesan, S., Roessle, M., Dick, T., Rao, S., Hunke, C., and Grüber, G. (2013) Variations of subunit ɛ of the Mycobacterium tuberculosis F1FO ATP synthase and a novel model for mechanism of action of the TB drug TMC207. Antimicrob. Agents Chemother. 57, 168-176

6. Basak, S., Lim, J., Manimekalai, M. S. S., Balakrishna, A. M., and Grüber, G. (2013) Crystal- and NMR structures give insights into the role and dynamics of subunit F of the eukaryotic V-ATPase from Saccharomyces cerevisiae. J. Biol. Chem. 288, 11930-11939

7. Balakrishna, A. M., Basak, S., Manimekalai, M. S. S., and Grüber, G. (2015) Crystal structure of subunits D and F in complex give insight into energy transmission of the eukaryotic V-ATPase from Saccharomyces cerevisiae. J. Biol. Chem. 290, 3183-3196

8. Nartey, W., Basak, S., Kamariah, N., Manimekalai, M. S. S., Robson, S., Wagner, G., Eisenhaber, B., Eisenhaber, F. and Grüber, G. (2015) NMR studies reveal a novel grab and release mechanism necessary for efficient catalysis of the bacterial 2-Cys peroxiridoxin machinery. FEBS J. 282, 4620-4638