Dr. Chong Shi Min Sherilyn, PhD

PhD Thesis:

Enzymatic and structural insights into the mycobacterial alkylhydroperoxide reductase subunit C and repurposing of an antimalaria compound inhibiting the mycobacterial cytochrome bcc oxidase for tuberculosis disease. Degree in 2020

Publications:

1. Harikishore, A., Chong, S. S. M., Ragunathan, P., Bates, R. W., and Grüber, G.* (2020) Targeting the menaquinol binding loop of mycobacterial cytochrome bd oxidase. Mol. Div., doi: 10.1007/s11030-020-10034-0

2. Chong, S. S. M., Manimekalai, M.S.S., Sarathy, J., Williams, Z., Harold, L., Cook, G.M.C., Dick, T., Pethe, K., Bates, R.W., and Grüber, G.* (2020) Anti-tuberculosis activity of the anti-malaria cytochrome bcc oxidase inhibitor SCR0911. ACS Infect. Dis. 6, 725-737

3. Chong, S. S. M., Kamariah, N., and Grüber, G.* (2020) Critical residues of helix ɑ2 for catalytic efficiency of Mycobacterial Alkylhydroperoxide reductase subunit C. FEBS Lett. 594, 2829-2839

4. Lee, B.S., Hards, K., Engelhart, C.A., Hasenoehrl, E.J., Kalia, N.P., Mackenzie, J.S., Sviriaeva, E., Chong, S.M.S., Manimekalai, M.S.S., Koh, V.H., Chan, J., Xu, J., Alonso, S., Miller, M.J., Steyn, Grüber, G., Schnappinger, D., Berney, M., Cook, G.M., Moraski, G.C., and Pethe, K. (2021) Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis. EMBO Mol. Med., e13207