Dr. Harikishore Amaravadhi, PhD

Nanyang Technological University

School of Biological Sciences
60 Nanyang Drive
Singapore 637551

Email: amaravadhi@ntu.edu.sg  

Publications:

1. Alag, R., Bharatham, N., Dong, A., Hills, T., Harikishore, A., Widjaja, A.A., Shochat, S.G., Hui, R. and Yoon, H.S. (2009) Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide. Protein Sci. 18, 2115-2124

2. Chattopadhaya, S., Harikishore, A. and Yoon, H.S. (2011) Role of FK506 binding proteins in neurodegenerative disorders. Curr. Med. Chem. 18, 5380-5397

3. Chakraborty, G., Shin, J., Nguyen, Q.T., Harikishore, A., Baek, K. and Yoon, H.S. (2012) Solution structure of FK506-binding protein 12 from Aedes aegypti. Proteins 80, 2476-2481

4. Ye, H., Li, B., Subramanian, V., Choi, B.H., Liang, Y., Harikishore, A., Chakraborty, G., Baek, K. and Yoon, H.S. (2013) NMR solution structure of C2 domain of MFG-E8 and insights into its molecular recognition with phosphatidylserine. Biochim. Biophys. Acta 1828, 1083-1093

5. Harikishore, A., Niang, M., Rajan, S., Preiser, P.R. and Yoon, H.S. (2013) Small molecule Plasmodium FKBP35 inhibitor as a potential antimalaria agent. Sci. Rep. 3, 2501

6. Harikishore, A., Leow, M.L., Niang, M., Rajan, S., Pasunooti, K.K., Preiser, P.R., Liu, X. and Yoon, H.S. (2013) Adamantyl derivative as a potent inhibitor of Plasmodium FK506 binding protein 35. ACS Med. Chem. Lett. 4, 1097-1101

7. Shin, J.C., Jung, H.Y., Harikishore, A., Kwon, O.D., Yoon, H.S., Kim, K.T. and Choi, B.H. (2014) The flavonoid myricetin reduces nocturnal melatonin levels in the blood through the inhibition of serotonin N-acetyltransferase. Biochem. Biophys. Res. Commun. 440, 312-316

8. Kwon, H.S., Cho, S.J., Ha, T.J., Harikishore, A., Yoon, H.S., Park, K.H., Kim, I.S. and Jang, D.S. (2014) Lipoxygenase inhibitory effects of dibenzylbutane lignans from the seeds of Myristica fragrans (Nutmeg). Bull. Korean Chem. Soc. 35, 3095-3098

9. Rajan, S., Austin, D., Harikishore, A., Nguyen, Q.T., Baek, K. and Yoon, H.S. (2014) Crystal structure of Plasmodium vivax FK506-binding protein 25 reveals conformational changes responsible for its noncanonical activity. Proteins 82, 1235-1244

10. Harikishore, A., Baek, K. and Yoon, H.S. (2014). Revisiting de novo drug design: Receptor based pharmacophore screening. Curr. Topi. Med. Chem. 14, 1890-1898

11. Choi, B.H., Chattopadhaya, S., Thanh, le. N., Feng, L., Nguyen, Q.T., Lim, C.B., Harikishore, A., Nanga, R.P., Bharatham, N., Zhao, Y., Liu, X. and Yoon, H.S. (2014) Suprafenacine, an indazole-hydrazide agent, targets cancer cells through microtubule destabilization. PLoS One 9, e110955

12. Kim, Y.S., Kim, S.H., Shin, J., Harikishore, A., Lim, J.K., Jung, Y., Lyu, H.N., Baek, N.I., Choi, K.Y., Yoon, H.S. and Kim, K.T. (2014) Luteolin suppresses cancer cell proliferation by targeting vaccinia-related kinase 1. PLoS One 9, e109655

13. Harikishore, A. and Yoon, H.S. (2015) Immunophilins: structures, mechanisms and ligands. Curr. Mol. Pharmacol. 8, 1-11

14. Harikishore, A., Li, E., Lee, J.J., Cho, N.J. and Yoon, H.S. (2015) Combination of pharmacophore hypothesis and molecular docking to identify novel inhibitors targeting thumb site II of HCV NS5B polymerase. Molec. Divers., in press

15. Saw, W.-G.¹, Wu, M.-L¹, Ragunathan, P.¹, Biuković, G, Lau, A.-M., Shin, J., Harikishore, A., Cheung, C.-Y., Hards, K., Sarathy, J. P., Bates, R. W., Cook, G. M. C., Dick, T.*, and Grüber, G.* (2019) Disrupting coupling within mycobacterial F-ATPsynthase subunit ε causes dysregulated energy production and cell wall biosynthesis. Sci. Rep. 9, 16759

16. Harikishore, A., Chong, S. S. M., Ragunathan, P., Bates, R. W., and Grüber, G.* (2020) Targeting the menaquinol binding loop of mycobacterial cytochrome bd oxidase. Mol. Div., doi: 10.1007/s11030-020-10034-0

17. Hotra, A., Ragunathan P., Ng, P.S., Seankongsuk, P., Harikishore, A., Sarathy, J.P., Saw, W.-G., Lakshmanan, U., Sae-Lao, P., Kalia, N.P., Shin, J., Kalyanasundaram, R., Anbarasu, S., Parthasarathy, K., Pradeep, C.N., Makhija, H., Dröge, P., Poulsen, A., Tan, J.H.L., Pethe, K., Dick, T., Bates, R.W., and Grüber, G.* (2020) Discovery of a novel Mycobacterial F-ATP synthase inhibitor and its potency in combination with diarylquinolines. Angewandte Chemie i.Ed, 132, 13397-13406

18. Wong, C.-F., Lau, A.-M., Harikishore, A., Saw, W.-G., Shin J., Ragunathan, P., Bhushan, S., Ngan, S. F. C., Sze, S. K., Bates, R.W., Dick, T., and Grüber, G.* (2021) A systematic assessment of mycobacterial F1-ATPase subunit ε’s role in latent ATPase hydrolysis. FEBS J. 288, 818-836

19. Harikishore, A., Wong, C.-F., Ragunathan, P., Litty, D., Müller, V., and Grüber, G.* (2021) Targeting mycobacterial F-ATP synthase C-terminal α subunit interaction motif on rotary subunit γ. Antibiotics 10, 1456

20. Harikishore, A., Saw, W.-G., Ragunathan, P., Litty, D., Dick, T., Müller, V., and Grüber, G.* (2022) Mutational analysis of mycobacterial F-ATP synthase subunit δ leads to a potent δ enzyme inhibitor. ACS Chem. Biol. 17, 529-535

21. Shin, J., Harikishore, A., Wong, C.-F., Ragunathan, P., Dick, T., and Grüber, G.* (2022) Atomic solution structure of Mycobacterium abscessus F-ATP synthase subunit ε and identification of Ep1MabF1 as a targeted inhibitor. FEBS J. in press

22. Saw, W.-G., Leow, C.Y., Harikishore, A., Shin, J., Cole, M., Aragaw, W.W., Ragunathan, P., Hegde, P., Aldrich, C.C., Dick, T., and Grüber, G.* (2022) Structural and mechanistic insights into Mycobacterium abscessus aspartate decarboxylase PanD and a pyrazinoic acid-derived inhibitor. ACS Infect. Dis., in press

¹ (Authors have equal contribution)