Dr. Goran Biuković, PhD

National University of Singapore

Singapore

Publications:

1. Rausch, H., Vešligaj, M., Počta,  D., Biuković,  G., Pigac,  J., Cullum,  J., Schmieger, H., and Hranueli, D. (1993) The temperate phages RP2 and RP3 of Streptomyces rimosus. J. Gen. Microbiol. 139, 2517-2524

2. Pandža, S., Biuković, G., Paravić, A., Dadbin, A., Cullum, J., and Hranueli, D. (1998) Recombination between the linear plasmid pPZG101 and the linear chromosome of Streptomyces rimosus can lead to exchange of ends. Mol. Microbiol. 28, 1165-76

3. Saito, A., Miyashita, K., Biuković, G., and Schrempf, H. (2001) Characteristics of a Streptomyces coelicolor A3(2) extracellular protein targeting chitin and chitosan. Appl. Environ. Microbiol. 67, 1268-1273

4. Schäfer, I., Rössle, M., Biuković, G., Müller, V. and Grüber, G. (2006) Structural and functional analysis of the coupling subunit F in solution and topological arrangement of the stalk domains of the methanogenic A1AO ATPsynthase. J. Bioenerg. Biomembr. 38, 83-92

5. Biuković, G., Rössle, M., Gayen, S., Mu, Y., and Grüber, G. (2007) Small-angle X-ray scattering reveals the solution structure of the peripheral stalk subunit H of the A1AO  ATP synthase from Methanocaldococcus jannaschii and its binding to the catalytic A subunit. Biochemistry 46, 2070-2078

6. Gayen, S., Vivekanandan, S., Biuković, G., Grüber, G., and Yoon, H. S. (2007) Backbone ¹H, ¹³C, and ¹⁵N resonance assignments of subunit F of the A1AO ATP synthase from Methanosarcina mazei Gö1. Biomol. NMR Assign. 1, 23-25

7. Gayen, S., Vivekanandan, S., Biuković, G., Grüber, G., and Yoon, H. S. (2007) The NMR solution structure of subunit F of the methanogenic A1AO ATP synthase and its interaction with the nucleotide-binding subunit B. Biochemistry 46, 11684-11694

8. Gayen, S., Balakrishna, A. M., Biuković, G., Yulei, W., Hunke, C. and Grüber, G. (2008) Identification of critical residues of subunit H in its interaction with subunit E of the A-ATP synthase from Methanocaldococcus jannaschii. FEBS J. 275, 1803-1812

9. Biuković, G.¹, Gayen, S.¹, Pervushin, K. and Grüber, G. (2009) The domain features of the peripheral stalk subunit H of the methanogenic A1AO ATP synthase and the NMR solution structure of H1-47. Biophys. J. 97, 286-294

10. Priya, R., Biuković, G., Gayen, S., Vivekanandan, S., and Grüber, G. (2009) Solution structure, determined by nuclear magnetic resonance, of the b30-82 domain of subunit b of Escherichia coli F1FO ATP synthase. J. Bacteriology 191, 7538-7544

11. Kumar, A., Manimekalai, M. S. S., Balakrishna, A. M., Priya, R., Biuković, G., Jeyakanthan, J., and Grüber, G. (2010) The critical roles of residues P235 and F236 of subunit A of the motor protein A-ATP synthase in P-loop formation and nucleotide-binding. J. Mol. Biol. 401, 892-905

12. Rose, I., Biuković, G., Aderhold, P., Müller, V., Grüber, G., and Averhoff, B. (2011) Identification and characterization of a unique, zinc-containing transport ATPase essential for natural transformation in Thermus thermophilus HB27. Extremophiles 15, 191-202

13. Zhang, Q., Hunke, C., Yau, Y. H., Seow, V., Lee, S., Tanner, L. B., Guan, X. L., Wenk, M. R., Fibriansah, G., Chew, P. L., Kukkaro, P., Biuković, G., Shi, P. Y., Shochat, S. G., Grüber, G., Lok, S. M. (2012) The stem region of premembrane protein plays an important role in the virus surface protein rearrangement during dengue maturation. J. Biol. Chem. 287, 40525-40534

14. Biuković, G., Basak, S., Manimekalai, M. S. S., Rishikesan, S., Roessle, M., Dick, T., Rao, S., Hunke, C., and Grüber, G. (2013) Variations of subunit ɛ of the Mycobacterium tuberculosis F1FO ATP synthase and a novel model for mechanism of action of the TB drug TMC207. Antimicrob. Agents Chemother. 57, 168-176

15. Priya, R., Biuković, G., Manimekalai, M. S. S., Lim, J., Rao, S. P. S., and Grüber, G. (2013) Solution structure of subunit γ (γ1-204) of the Mycobacterium tuberculosis F-ATP synthase and the unique loop of γ165-178, representing a novel TB drug target. J. Bioenerg. Biomembr. 45, 121-129

16. Salzer, R. Herzberg, M., Nies, D., Biuković, G., Grüber, G., Müller, V., and Averhoff, B. (2013) The DNA uptake ATPase PilF of Thermus thermophilus: a reexamination of the zinc content. Extremophiles 17, 697-698

17. Hotra, A., Suter, M., Biuković, G., Ragunathan, P., Kundu, S., Dick, T. and Grüber G. (2016) Deletion of a unique loop in the mycobacterial F-ATP synthase γ subunit sheds light in its inhibitory role in ATP hydrolysis driven H+-pumping. FEBS J. 283, 1947-1961

18. Kundu, S., Biuković, G., Grüber, G. and Dick, T. (2016) Bedaquiline targets the ε subunit of mycobacterial F-ATP synthase. Antimicrob. Agents Chemother. 60, 6977-6979

19. Sielaff, H., Martins, J. Singh, D., Biuković, G., Grüber, G.*, Frasch, W.* (2016) Power Stroke Angular Velocity Profiles of Archaeal A-ATP synthase versus Thermophilic and Mesophilic F-ATP synthase Molecular Motors. J. Biol, Chem. 291, 25351-35363

20. Ragunathan, P, Sielaff, H., Sundararaman, L., Biuković, G., Manimekalai, M.S.S., Singh, D., Kundu, S., Wohland, T., Frasch, W., Dick, T. and Grüber, G.* (2017) The uniqueness of subunit α of mycobacterial F-ATP synthases: An evolutionary variant for niche adaptation. J. Biol. Chem. 292, 11262-11279

21. Saw, W.-G.¹, Wu, M.-L¹, Ragunathan, P.¹, Biuković, G, Lau, A.-M., Shin, J., Harikishore, A., Cheung, C.-Y., Hards, K., Sarathy, J. P., Bates, R. W., Cook, G. M. C., Dick, T.*, and Grüber, G.* (2019) Disrupting coupling within mycobacterial F-ATPsynthase subunit ε causes dysregulated energy production and cell wall biosynthesis. Sci. Rep. 9, 16759

¹ (Authors have equal contribution)