Anil

Dr. Anil Kumar, PhD

ImmunOs Therapeutics AG

Schlieren, Switzerland

 

PhD Thesis:

The trail of nucleotides and the traits of ADP/ATP-binding inside the subunits A and B of the archaeal energy producer A1AO ATP synthase. Degree in 2010

Publications:

  1. Kumar, A., Manimekalai, M. S. S., and Grüber, G. (2008) Structure of the nucleotide binding subunit B of the energy producer A1AO ATP synthase in complex with adenosine diphosphate. Acta Cryst. D64, 1110–1115

  2. Kumar, A., Manimekalai, M. S. S., Balakrishna, A. M., Hunke, C., Weigelt, S., Sewald, N., and Grüber, G. (2009) Spectroscopic and crystallographic studies of the mutant R416W give insight into the nucleotide binding traits of subunit B of the A1AO ATP synthase. PROTEINS: Structure, Function and Bioinformatics 75, 807-819

  3. Manimekalai, M. S. S., Kumar, A., Balakrishna, A. M., and Grüber, G. (2009) A second transient position of ATP on its trail to the nucleotide-binding site of subunit B of the motor protein A1AO ATP synthase. J. Struct. Biol. 166, 39-45

  4. Kumar, A., Manimekalai, M. S. S., Balakrishna, A. M., Jeyakanthan, J., and Grüber, G. (2010) Nucleotide-binding states of subunit A of the A-ATP synthase and the implication of P-loop switch in evolution. J. Mol. Biol. 396, 301-320

  5. Kumar, A.1, Manimekalai, M. S. S.1, Balakrishna, A. M., Priya, R., Biuković, G., Jeyakanthan, J., and Grüber, G. (2010) The critical roles of residues P235 and F236 of subunit A of the motor protein A-ATP synthase in P-loop formation and nucleotide-binding. J. Mol. Biol. 401, 892-905

  6. Manimekalai, M. S. S.1, Kumar, A.1, Jeyakanthan, J., and Grüber, G. (2011) The transition-like state and Pi entrance into the catalytic A subunit of the biological engine A-ATP synthase. J. Mol. Biol., 408, 736-754

  7. Priya, R., Kumar, A., Manimekalai, M. S. S., and Grüber, G. (2011) Conserved glycine residues in the P-loop of ATP synthases form a doorframe for nucleotide entrance. J. Mol. Biol. 413, 657-666

  8. Raghunathan, D., Gayen, S., Kumar, A., Hunke, C., Grüber, G., and Verma, C. (2012) Subunit F modulates ATP binding and migration in the nucleotide-binding subunit B of the A1AO ATP synthase of Methanosarcina mazei Gö1. J. Bioenerg. Biomembr. 44, 213-224

1 (Authors have equal contribution)

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last update 23-Nov-2020