Dr. Asha M. Balakrishna, PhD

Publications:

  1. Karanth, N.G.K, Pasha, A., Amita Rani B.E., Asha, M.B., Udayakumari, C.G. and Vijayashankar, Y.N. (1999) Rapid tests for monitoring pesticide residues in the environment. Journ. Envir. Sci. 3, 1-10

  2. Balakrishna, A. M., Tan, Y.-W., Mok, H.Q.-K., Saxena, A. and Swaminathan , K. (2006) Crystallization and preliminary X-ray diffraction analysis of Salmonella typhi PilS dimer. Acta. Cryst. F62, 1024-1026

  3. Gayen, S., Balakrishna, A. M., Biuković, G., Yulei, W., Hunke, C. and Grüber, G. (2008) Identification of critical residues of subunit H in its interaction with subunit E of the A-ATP synthase from Methanocaldococcus jannaschii. FEBS J. 275, 1803-1812

  4. Kumar, A., Manimekalai, M. S. S., Balakrishna, A. M., Hunke, C., Weigelt, S., Sewald, N. and Grüber, G. (2009) Spectroscopic and crystallographic studies of the mutant R416W give insight into the nucleotide binding traits of subunit B of the A1AO ATP synthase. PROTEINS: Structure, Function and Bioinformatics 75, 807-819

  5. Manimekalai, M. S. S., Kumar, A., Balakrishna, A. M. and Grüber, G. (2009) A second transient position of ATP on its trail to the nucleotide-binding site of subunit B of the motor protein A1AO ATP synthase. J. Struct. Biol. 166, 39-45

  6. Gayen, S., Balakrishna, A. M. and Grüber, G. (2009) NMR solution structure of the N–terminal domain of subunit E (E1-52) of A1AO ATP synthase from Methanocaldococcus jannaschii. J. Bioenerg. Biomembr. 41, 343-348

  7. Kumar, A., Manimekalai, M. S. S., Balakrishna, A. M., Jeyakanthan, J., and Grüber, G. (2010) Nucleotide-binding states of subunit A of the A-ATP synthase and the implication of P-loop switch in evolution. J. Mol. Biol. 396, 301-320

  8. Balakrishna, A. M.1, Hunke, C.1 and Grüber, G. (2010) Purification and crystallization of the entire recombinant subunit E of the energy producer A1AO ATP synthase. Acta. Cryst. F66, 324-326

  9. Grüber, A., Manimekalai, M. S. S., Balakrishna, A. M., Hunke, C., Jeyakanthan, J., Preiser, P. and Grüber, G. (2010) Structural determination of functional units of the nucleotide binding domain (NBD94) of the reticulocyte binding protein Py235 of Plasmodium yoelii. PLoS ONE 5, 9146-9157

  10. Balakrishna, A. M., Manimekalai, M. S. S,. Hunke, C., Gayen, S., Rössle, M., Jeyakanthan, J. and Grüber, G. (2010) Crystal and solution structure of the C-terminal part of the Methanocaldococcus jannaschii A1AO ATP synthase subunit E revealed by X-ray diffraction and small-angle X-ray scattering. J. Bioenerg. Biomembr. 42, 311-320

  11. Kumar, A., Manimekalai, M. S. S., Balakrishna, A. M., Priya, R., Biuković, G., Jeyakanthan, J., and Grüber, G. (2010) The critical roles of residues P235 and F236 of subunit A of the motor protein A-ATP synthase in P-loop formation and nucleotide-binding. J. Mol. Biol. 401, 892-905

  12. Balakrishna, A. M., Hunke, C., and Grüber, G. (2012) The structure of subunit E of the Pyrococcus horikoshii OT3 A-ATP synthase gives insight into the elasticity of the peripheral stalk. J. Mol. Biol., 420, 155-163

  13. Basak, S., Balakrishna, A. M., Manimekalai, M. S. S., and Grüber, G. (2012) Crystallization and preliminary X-ray crystallographic analysis of subunit F, F1-94, an essential coupling subunit of the eukaryotic V1VO ATPase from Saccharomyces cerevisiae. Acta Cryst. F68, 1055-1059

  14. Alag, R., Balakrishna, A. M., Rajan, S., Qureshi, I., Shin, J., Lescar, J., Grüber, G., and Yoon, H. S. (2013) Structural insights into substrate binding by PvFKBP35, a peptidylprolyl cis-trans isomerase from the human malarial parasite Plasmodium vivax. Eukaryotic Cell, in press

  15. Basak, S., Lim, J., Manimekalai, M. S. S., Balakrishna, A. M., and Grüber, G. (2013) Crystal- and NMR structures give insights into the role and dynamics of subunit F of the eukaryotic V-ATPase from Saccharomyces cerevisiae. J. Biol. Chem. 288, 11930-11939

  16. Balakrishna, A. M., Seelert, H., Marx, S.-H. Dencher, N.A., and Grüber, G. (2014) Crystallographic structure of the turbine c-ring from spinach chloroplast F-ATP synthase. Biosci. Rep. 34, e00102

  17. Dip, P. V., Kamariah, N., Manimekalai, M. S. S., Nartey, W., Balakrishna, A. M., Eisenhaber, F., Eisenhaber, B. and Grüber, G. (2014) Structure, mechanism and ensemble formation of the Alkylhydroperoxide Reductase subunits AhpC and AhpF from Escherichia coli. Acta Crystallogr. D70, 2848-2862

  18. Balakrishna, A. M., Basak, S., Manimekalai, M. S. S., and Grüber, G.* (2015) Crystal structure of subunits D and F in complex give insight into energy transmission of the eukaryotic V-ATPase from Saccharomyces cerevisiae. J. Biol. Chem. 290, 3183-3196

  19. Balakrishna, A. M., Manimekalai, M. S. S., and Grüber, G. (2015) Protein-protein interactions within the ensemble, Eukaryotic V-ATPase, and its concerted interactions with cellular machineries. Progr. Biophys. Mol. Biol. 119, 84-93

  20. Kumar, A., Balakrishna, A. M.1, Nartey, W.1, Manimekalai, M. S. S., and Grüber, G. (2016) Redox chemistry of Mycobacterium tuberculosis alkylhydroperoxide reductase E (AhpE): Structural and mechanistic insight into a mycoredoxin-1 independent reductive pathway of AhpE via mycothiol. Free Rad. Biol. Med. 97, 588-601

  21. Singal, B., Balakrishna, A., Nartey, W., Manimekalai, M.S.S., Jeyakanthan, J. and Grüber, G.* (2017) Crystallographic and solution structure of the N-terminal domain of the Rel protein from Mycobacterium tuberculosis. FEBS Letters 591, 2323-2337

  22. Toh, Y.K., Balakrishna, A.M., Manimekalai, M.S.S., Chionh, B.B., Seetharaman, R.R.C., Eisenhaber, B., Eisenhaber, F. and Grüber, G. (2017) Novel insights into the vancomycin-resistant Enterococcus faecalis (V583) alkylhydroperoxide reductase subunit F. Biochim. Biophys. Acta-General Subject 1861, 3201-3214

  23. Pan, A., Balakrishna, A.M., Nartey, W., Kohlmeier, A., Dip, P.V., Bhushan, S., Grüber, G.* (2018) Atomic structure and enzymatic insights into the vancomycin-resistant Enterococcus faecalis (V583) alkylhydroperoxide reductase subunit C. Free Rad. Biol. Med. 115, 252-265

  24. Toh, Y.K., Balakrishna, A., Shin, J., Neelagandan, K., Grüber, A., Eisenhaber, F., Eisenhaber, B. and Grüber, G.* (2019) Effect of the additional cysteine 503 of vancomycin-resistant Enterococcus faecalis (V583) alkylhydroperoxide reductase subunit F (AhpF) and the mechanism of AhpF and subunit C assembling. Free Rad. Med. Biol. 138, 10-22

1 (Authors have equal contribution)

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last update 23-Nov-2020