Dr. Cornelia Hunke, PhD

 

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Diploma Thesis:

Wechselwirkungen von Aktin mit der V-ATPase. Degree in 2001 at the University of Osnabrück/Germany

PhD Thesis:

Synthetische Mimetika der Bindungsstelle der Mena-EVH1-Domäne für prolinreiche Liganden: Design, Synthese und Untersuchung des Bindungsverhaltens. Degree in 2005 at the University of Braunschweig/Germany

Publications:

  1. Mieschendahl, M., Finkernagel, K., Hunke, C., and Spranz, E. (1992) Biological safety investigations of the production of human insulin by genetically engineered E. coli K-12 cells. 1. Survival capacity of the production strain in the digestive tract of Gottinger miniature swine. Zentralbl. Hyg. Umweltmed. 193, 342-349

  2. Hunke, C., Hirsch, T., and Eichler, J. (2006) Structure-based synthetic mimicry of discontinuous protein binding sites: inhibitors of the interaction of Mena EVH1 domain with proline-rich ligands. Chembiochem. 7, 1258-1264

  3. Hunke, C., Chen, W.-Y., Schäfer, H.-J., and Grüber, G. (2007) Cloning, purification, and nucleotide-binding traits of the catalytic subunit A of the catalytic V1VO ATPase from Aedes albopictus. Prot. Expr. Purif. 53, 378-383

  4. Luo, D. H., Xu, T., Hunke, C., Grüber, G., Vasudevan, S. G., and  Lescar, J. (2008)  Crystal structure of the NS3 protease-helicase from Dengue virus. J. Virol. 82, 173-183

  5. Gayen, S., Balakrishna, A. M., Biuković, G., Yulei, W., Hunke, C., and Grüber, G. (2008) Identification of critical residues of subunit H in its interaction with subunit E of the A-ATP synthase from Methanocaldococcus jannaschii. FEBS J. 275, 1803-1812

  6. Rishikesan, S., Thaker, R. Y., Priya, R., Gayen, S., Manimekalai, M. S. S., Hunke, C., and Grüber, G. (2008) Spectroscopical identification of residues of subunit G of the yeast V-ATPase in its connection with subunit E. Mol. Mem. Biol. 25, 400-410

  7. Priya, R., Tadwal, V. S., Rössle, M., Gayen, S., Hunke, C., Peng, W. C., Torres, J., and Grüber, G. (2008) Low resolution structure of subunit b (b22-156) of Escherichia coli F1FO ATP synthase in solution and the b-d assembly. J. Bioenerg. Biomembr. 40, 245-255

  8. Ramalingam, J. K.1, Hunke, C.1, Gao, X., Grüber, G., and Preiser, P.R. (2008) ATP/ADP-binding to a novel nucleotide binding domain of the reticulocyte binding protein Py235 of Plasmodium yoelii. J. Biol. Chem. 283, 36389-36396

  9. Kumar, A., Manimekalai, M. S. S., Balakrishna, A. M., Hunke, C., Weigelt, S., Sewald, N., and Grüber, G. (2009) Spectroscopic and crystallographic studies of the mutant R416W give insight into the nucleotide binding traits of subunit B of the A1AO ATP synthase. PROTEINS: Structure, Function and Bioinformatics 75, 807-819

  10. Thaker, R. Y.1, Hunke, C.1, Yau, Y. H., Greifman Shochat, S., Ying, L., and Grüber, G. (2009) Association of the eukaryotic V1VO ATPase subunits a with d and d with A. FEBS Lett. 583, 1090-1095

  11. Link, N. M., Hunke, C., Mueller, J. W., Eichler, J., and Bayer P. (2009)  The solution structure of pGolemi, a high affinity Mena EVH1 binding miniature protein, suggests explanations for paralog-specific binding to Ena/VASP homology (EVH) 1 domains. Biol. Chem. 390, 417-426

  12. Hunke, C.1, Tadwal, V. S.1, Manimekalai, M. S. S., Rössle, M., and Grüber, G. (2010) The effect of NBD-Cl in nucleotide-binding of the major subunit a and B of the motor proteins F1FO ATP synthase and A1AO ATP synthase. J. Bioenerg. Biomembr. 42, 1-10

  13. Balakrishna, A. M.1, Hunke, C.1, and Grüber, G. (2010) Purification and crystallization of the entire recombinant subunit E of the energy producer A1AO ATP synthase. Acta. Cryst. F66, 324-326

  14. Grüber, A., Manimekalai, M. S. S., Balakrishna, A. M., Hunke, C., Jeyakanthan, J., Preiser, P., and Grüber, G. (2010) Structural determination of functional units of the nucleotide binding domain (NBD94) of the reticulocyte binding protein Py235 of Plasmodium yoelii. PLoS ONE 5, 9146-9157

  15. Balakrishna, A. M., Manimekalai, M. S. S., Hunke, C., Gayen, S., Rössle, M., Jeyakanthan, J., and Grüber, G. (2010) Crystal and solution structure of the C-terminal part of the Methanocaldococcus jannaschii A1AO ATP synthase subunit E revealed by X-ray diffraction and small-angle X-ray scattering. J. Bioenerg. Biomembr. 42, 311-320

  16. Basak, S., Gayen, S., Thaker, Y. R., Manimekalai, M. S. S., Roessle, M., Hunke, C., and Grüber, G. (2011) Solution structure of subunit F (Vma7p) of the eukaryotic V1VO ATPase from Saccharomyces cerevisiae derived from SAXS and NMR spectroscopy. Biochim. Biophys. Acta-Biomembranes 1808, 360-368

  17. Hunke, C., Antosch, M., Müller, V., and Grüber, G. (2011) Binding of subunit E into the A-B interface of the A1AO ATP synthase. Biochim. Biophys. Acta-Biomembranes, 1808, 2111–2118

  18. Raghunathan, D., Gayen, S., Kumar, A., Hunke, C., Grüber, G., and Verma, C. (2012) Subunit F modulates ATP binding and migration in the nucleotide-binding subunit B of the A1AO ATP synthase of Methanosarcina mazei Gö1. J. Bioenerg. Biomembr. 44, 213-224

  19. Balakrishna, A. M., Hunke, C., and Grüber, G. (2012) The structure of subunit E of the Pyrococcus horikoshii OT3 A-ATP synthase gives insight into the elasticity of the peripheral stalk. J. Mol. Biol., 420, 155-163

  20. Tadwal, V. S., Sundararaman, L., Manimekalai, M. S. S., Hunke, C., and Grüber, G. (2012) Relevance of the conserved histidine and asparagine residues in the phosphate-binding loop of the nucleotide binding subunit B of A1AO ATP synthases. J. Struct. Biol. 180, 509-518

  21. Zhang, Q., Hunke, C., Yau, Y. H., Seow, V., Lee, S., Tanner, L. B., Guan, X. L., Wenk, M. R., Fibriansah, G., Chew, P. L., Kukkaro, P., Biuković, G., Shi, P. Y., Shochat, S. G., Grüber, G., Lok, S. M. (2012) The stem region of premembrane protein plays an important role in the virus surface protein rearrangement during dengue maturation. J. Biol. Chem. 287, 40525-40534

  22. Biuković, G., Basak, S., Manimekalai, M. S. S., Rishikesan, S., Roessle, M., Dick, T., Rao, S., Hunke, C., and Grüber, G. (2013) Variations of subunit ɛ of the Mycobacterium tuberculosis F1FO ATP synthase and a novel model for mechanism of action of the TB drug TMC207. Antimicrob. Agents Chemother. 57, 168-176

  23. Wei, L., Jiang, P., Manimekalai, M. S. S., Hunke, C., Grüber, G., Pervushin, K. and Mu, Y. (2015) Extended structure of rat islet amyloid polypeptide in solution. Adv. Exp. Med. Biol., Dongqing Wei et al. (Eds): Advance in Structural Bioinformatics 827, 85-92

1 (Authors have equal contribution)

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last update 23-Nov-2020