Dr. Phat Vinh Dip, PhD

Nanoimaging Services (NIS)

Boston, USA

PhD Thesis:

Structural and functional insights into subunit a of Saccharomyces cerevisiae V-ATPase and the Escherichia coli Alkyl Hydroperoxide Reductase complex

Publications:

1. Osman C., Haag M., Potting C., Rodenfels J., Dip P. V., Wieland F. T., Brügger B., Westermann B., Langer T. (2009)  The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. J. Cell Bio. 184, 583-589

2. Merkulova, M., McKee, M., Dip, P. V., Grüber, G. and Marshansky, M. (2010) N-terminal domain of the V-ATPase a2-subunit displays integral membrane protein properties. Protein Science 19, 1850-1862

3. Dip, P. V.¹, Saw, W. G.¹, Roessle, M., Marshansky, V., and Grüber, G. (2012) Solution structure of subunit a, a104-363, of the Saccharomyces cerevisiae V-ATPase and the importance of its C-terminus in structure formation. J. Bioenerg. Biomembr. 44, 341-350

4. Hosokawa, H., Dip, P. V., Merkulova, M., Zhuang, Z., Khatri, A., Jian, X., Keating, S. M., Bueler, S. A., Rubinstein, J. L., Randazzo, P. A., Ausiello, D. A., Grüber, G., and Marshansky, M. (2013) N-terminal part of a-subunit isoforms is involved in signaling between V-ATPase and Cytohesin-2. J. Biol. Chem. 288, 5896-5913

5. Dip, P. V., Kamariah, N., Manimekalai, M. S. S., Nartey, W., Balakrishna, A. M., Eisenhaber, F., Eisenhaber, B. and Grüber, G. (2014) Structure, mechanism and ensemble formation of the Alkylhydroperoxide Reductase subunits AhpC and AhpF from Escherichia coli. Acta Crystallogr. D70, 2848-2862

6. Dip, P. V.¹, Kamariah, N.¹, Nartey, W.¹, Beushausen, C., Kostyuchenko, V. A., Ng, T. S., Lok, S. M., Saw, W. G., Eisenhaber, F., Eisenhaber, B. and Grüber, G. (2014) Key roles for the Escherichia coli AhpC C-terminus in assembly and catalysis of alkylhydroperoxide reductase, an enzyme essential for the alleviation of oxidative stress. Biochim. Biophys. Acta 1837, 1932-1943

7. Pan, A., Balakrishna, A.M., Nartey, W., Kohlmeier, A., Dip, P.V., Bhushan, S., Grüber, G.* (2018) Atomic structure and enzymatic insights into the vancomycin-resistant Enterococcus faecalis (V583) alkylhydroperoxide reductase subunit C. Free Rad. Biol. Med. 115, 252-265

8. Marshansky, V., Hosokawa, H., Merkulova, M., Bakulina, A., Bjargava, A., Tonra, J., Dip, P.V., Thaker, Y.R., and Grüber, G. (2019) Structural model of a2-subunit N-terminus and its binding interface for Arf-GEF CTH2: Implication for regulation of V-ATPase, CTH2 function and rational drug design. Curr. Top. Membr. 83, 77-106

¹ (Authors have equal contribution)