Dr. Shin Joon, PhD

Nanyang Technological University

School of Biological Sciences
60 Nanyang Drive
Singapore 637551

Email: shinjoonee@ntu.edu.sg

Publications:

  1. Lee, C.H., Hong, H., Shin, J., Jung, M., Shin, I., Yoon, J. and Lee, W. (2000) NMR studies on novel antitumor drug candidates, deoxoartemisinin and carboxypropyldeoxoartemisinin. Biochem. Biophys. Res. Commun. 274, 359-369

  2. Sung, Y.H., Shin, J., Chang, H.J., Cho, J.M. and Lee, W. (2001) Solution structure, backbone dynamics, and stability of a double mutant single-chain monellin. structural origin of sweetness. J. Biol. Chem. 276, 19624-19630

  3. Hong, E., Shin, J., Bang, E., Kim, M.H., Lee, S.T., Lee, W. (2001) Complete sequence-specific 1H, 13C and 15N resonance assignments of the human PTK6 SH2 domain. J. Biomol. NMR 19, 291-292

  4. Shin, J., Lee, W., Lee, D., Koo, B.K., Han, I., Lim, Y., Woods, A., Couchman, J.R. and Oh, E.S. (2001) Solution structure of the dimeric cytoplasmic domain of syndecan-4. Biochemistry 40, 8471-8478

  5. Sung, Y.H., Shin, J., Shin, J. and Lee, W. (2001) Solution structure of p21(Waf1/Cip1/Sdi1) C-terminal domain bound to Cdk4. J. Biomol. Struct. Dyn. 19, 419-427

  6. Kim, M.S., Shin, J., Lee, W., Lee, H.S. and Oh, B.H. (2003) Crystal structures of RbsD leading to the identification of cytoplasmic sugar-binding proteins with a novel folding architecture. J. Biol. Chem. 278, 28173-28180

  7. Ko, S.G., Shin, J., Yu, E.Y., Chung, I.K., Tanaka, T. and Lee, W. (2003) 1H, 13C and 15N resonance assignments of rice telomere binding domain from Oryza sativa. J. Biomol. NMR 27, 89-90

  8. Woo, J.S., Jung, J.S., Ha, N.C., Shin, J., Kim, K.H., Lee, W. and Oh, B.H. (2003) Unique structural features of a BCL-2 family protein CED-9 and biophysical characterization of CED-9/EGL-1 interactions. Cell Death Differ. 10, 1310-1319

  9. Cho, M.K., Kim, S.S., Lee, M.R., Shin, J., Lee, J., Lim, S.K., Baik, J.H., Yoon, C.J., Shin, I. and Lee, W. (2003) NMR studies on turn mimetic analogs derived from melanocyte-stimulating hormones. J. Biochem. Mol. Biol. 36, 552-557

  10. Shin, J., Hong, S.Y., Chung, K., Kang, I., Jang, Y., Kim, D.S. and Lee, W. (2003) Solution structure of a novel disintegrin, salmosin, from Agkistrondon halys venom. Biochemistry 42, 14408-14415

  11. Hong, E., Jung, J.W., Shin, J., Kim, J.H., Jeon, Y.H., Yamazaki, T. and Lee, W. (2004) Backbone 1H, 13C and 15N resonance assignments of the response regulator HP1043 from Helicobacter pylori. J. Biomol. NMR 28, 85-86

  12. Hong, E., Shin, J., Kim, H.I., Lee, S.T. and Lee, W. (2004) Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain. J. Biol. Chem. 279, 29700-29708

  13. Hong, E., Shin, J., Kang, S.W., Tanaka, T. and Lee, W. (2005) Resonance assignments and secondary structure of hPrxVI, a 25 kDa 1-cys human peroxiredoxin enzyme. J. Biomol. NMR 31, 267-268

  14. Koo, B.K., Jung, Y.S., Shin, J., Han, I., Mortier, E., Zimmermann, P., Whiteford, J.R., Couchman, J.R., Oh, E.S. and Lee, W. (2006) Structural basis of syndecan-4 phosphorylation as a molecular switch to regulate signaling. J. Mol. Biol. 355, 651-663

  15. Hong, E., Lee, H.M., Ko, H., Kim, D.U., Jeon, B.Y., Jung, J., Shin, J., Lee, S.A., Kim, Y., Jeon, Y.H., Cheong, C., Cho, H.S. and Lee, W. (2007) Structure of an atypical orphan response regulator protein supports a new phosphorylation-independent regulatory mechanism. J. Biol. Chem. 282, 20667-20675

  16. Shin, J., Kim, Y.M., Li, S.Z., Lim, S.K. and Lee, W. (2008) Structure-function of the TNF receptor-like cystein-rich domain of osteoprotegrin. Mol. Cells 25, 352-357

  17. Shin, J., Lee, W. and Lee, W. (2008) Structural proteomics by NMR spectroscopy (Review). Expert. Rev. Proteomics 5, 589-601

  18. Alag, R., Shin, J. and Yoon, H.S. (2009) NMR assignments of the FK506-binding domain of FK506-binding protein 35 from Plasmodium vivax. Biomol. NMR Assign. 3, 243-245

  19. Ko, S., Yu, E.Y., Shin, J., Yoo, H.H., Tanaka, T., Kim, W.T., Cho, H.S., Lee, W. and Chung, I.K. (2009) Solution structure of the DNA binding domain of rice telomere binding protein RTBP1. Biochemistry 48, 827-838

  20. Alag, R., Qureshi, I.A., Bharatham, N., Shin, J., Lescar, J. and Yoon, H.S. (2010) NMR and crystallographic structures of the FK506 binding domain of human malarial parasite Plasmodium vivax FKBP35. Protein Sci. 19, 1577-1586

  21. Shin, J., Chakraborty, G., Bharatham, N., Kang, C., Tochio, N., Koshiba, S., Kigawa, T., Kim, W., Kim, K.T. and Yoon, H.S. (2011) NMR solution structure of human vaccinia-related kinase 1 (VRK1) reveals the C-terminal tail essential for its structural stability and autocatalytic activity. J. Biol. Chem. 286, 22131-22138

  22. Kim, W., Chakraborty, G., Kim, S., Shin, J., Park, C.H., Jeong, M.W., Bharatham, N., Yoon, H.S. and Kim, K.T. (2012) Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase. J. Biol. Chem. 287, 5278-5289

  23. Chakraborty, G., Shin, J., Nguyen, Q.T., Harikishore, A., Baek, K. and Yoon, H.S. (2012) Solution structure of FK506-binding protein 12 from Aedes aegypti. Proteins 80, 2476-2481

  24. Alag, R.. Balakrishina, A.M., Rajan, S., Qureshi, I.A., Shin, J., Lescar, J., Gruber, G. and Yoon H.S. (2013) Structural insights into substrate binding by PvFKBP35, a peptidyl cis-trans isomerase from the human malarial parasite Plasmodium vivax. Eukaryot. Cell 12, 627-634

  25. Moon, S., Shin, J., Lee, D., Seong, R.H. and Lee, W. (2013) 1H, 15N, and 13C resonance assignments and secondary structure of the SWIRM domain of human BAF155, a chromatin remodeling complex component. Mol. Cells 36, 333-339

  26. Shin, J., Chakraborty, G. and Yoon, H.S. (2014) Backbone 1H,13C and 15N resonance assignments of human vaccinia-related kinase 1 (VRK1). Biomol. NMR Assign. 8, 29-31

  27. Kim, Y.S., Kim, S.H., Shin, J., Harikishore, A., Lim J.K., Jung, Y., Lyu, H.N., Baek, N.I., Choi, K.Y., Yoon, H.S. and Kim, K.T. (2014) Luteolin suppresses cancer cell proliferation by targeting vaccinia-related kinase 1. PLoS One 9, e109655

  28. Prakash, A., Shin, J. and Yoon, H.S. (2015) 1H, 13C and 15N resonance assignments of human FK506 binding protein 25. Biomol. NMR Assign. 9, 43-46

  29. Kim, C.H., Han, B.S., Moon, J., Kim, D.J., Shin, J., Rajan, S., Nguyen, Q.T., Sohn, M., Kim, W.G., Han, M., Jeong, I., Kim, K.S., Lee, E.H., Tu, Y., Naffin-Olivos, J.L., Park, C.H., Ringe, D., Yoon, H.S., Petsko, G.A. and Kim, K.S. (2015) Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease. Proc. Natl. Acad. Sci. USA 112, 8756-8761

  30. Kim, S.H., Ryu, H.G., Lee, J., Shin, J., Harikishore, A., Jung, H.Y., Kim, Y.S., Lyu, H.N., Oh, E., Baek, N.I., Choi, K.Y., Yoon, H.S. and Kim, K.T. (2015) Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells. Sci. Rep. 5, 14570

  31. Kini, S.G., Nguyen, P.Q., Weissbach, S., Mallagaray, A., Shin, J., Yoon, H.S. and Tam, J.P. (2015) Studies on the Chitin Binding Property of Novel Cysteine-Rich Peptides from Alternanthera sessilis. Biochemistry 54, 6639-6649

  32. Pan, A., Saw, W.G., Manimekalai, M.S.S., Grüber, A., Shin, J., Matsui, T., Weiss, T. and Grüber, G.* (2017) Structural features of NS3 of Dengue virus serotypes 2 and 4 in solution and insight into RNA binding and the inhibitory role of quercetin. Acta Crystallogr. D73, 402-419

  33. Kumar, A., Nartey, W., Shin, J., Manimekalai, M. S. S., and Grüber, G. (2017) Structural and mechanistic insights into Mycothiol Disulphide Reductase and the Mycoredoxin-1-alkylhydroperoxide reductase E assembly of Mycobacterium tuberculosis. Biochim. Biophys. Acta-General Subject 1861, 2354-2366

  34. Wong, C.F., Shin, J., Manimekalai, M.S.S., Saw, W.G., Zhan, Y., Bhushan, S. Kumar, A., Ragunathan, P. and Grüber, G.* (2017) The uniqueness of AhpC of the mycobacterial antioxidant defense system and its interaction with its reducing partner Thioredoxin-C. Sci. Rep. 7, 5159

  35. Shin, J., Ragunathan, P., Sundararaman, L., Nartey, W., Kundu, S., Manimekalai, M.S.S., Bogdanović, N., Dick, T. and Grüber, G.* (2018) The NMR solution structure of Mycobacterium tuberculosis F-ATP synthase subunit ε provides new insight into energy coupling inside the rotary engine. FEBS J. 285, 1111-1128

  36. Bogdanović, N, Sundararaman, L., Kamariah, N., Tyagi, A., Bhushan, S., Ragunathan, P., Shin, J., Dick, T., and Grüber, G.* (2018) Structure and function of Mycobacterium-specific components of F-ATP synthase subunits α and ε. J. Struct. Biol. 280, 420-434

  37. Toh, Y.K., Balakrishna, A., Shin, J., Neelagandan, K., Grüber, A., Eisenhaber, F., Eisenhaber, B. and Grüber, G.* (2019) Effect of the additional cysteine 503 of vancomycin-resistant Enterococcus faecalis (V583) alkylhydroperoxide reductase subunit F (AhpF) and the mechanism of AhpF and subunit C assembling. Free Rad. Med. Biol. 138, 10-22

  38. Sarathy, J., Ragunathan, P., Shin, J., Cooper, C., Upton, A., Grüber, G.*, and Dick, T.* (2019) TBAJ-876 retains Bedaquiline’s activity against subunit c and ε of Mycobacterium tuberculosis F-ATP synthase. Antimicrob. Agents Chemother. 63, e01191-19

  39. Saw, W.-G.1, Wu, M.-L1, Ragunathan, P.1, Biuković, G, Lau, A.-M., Shin, J., Harikishore, A., Cheung, C.-Y., Hards, K., Sarathy, J. P., Bates, R. W., Cook, G. M. C., Dick, T.*, and Grüber, G.* (2019) Disrupting coupling within mycobacterial F-ATPsynthase subunit ε causes dysregulated energy production and cell wall biosynthesis. Sci. Rep. 9, 16759

  40. Kamariah, N., Ragunathan, P., Shin, J., Saw, W.-G., Wong, C.F., Dick, T., and Grüber, G.* (2020) Unique structural and mechanistic properties of mycobacterial F-ATP synthases: Implications for drug design. Prog. Biophys. Mol. Biol. 152, 64-73

  41. Gopal, P., Sarathy, J., Yee, Y., Ragunathan, P., Shin, J., Bhushan, S., Zhu, J., Akopian, T., Kandror, O., Lim, T.K., Gengenbacher, M., Lin, Q., Rubin, E.J., Grüber, G., and Dick, T. (2020) Pyrazinamide triggers degradation of its target aspartate decarboxylase. Nature Commun. 11, 1661

  42. Hotra, A., Ragunathan P., Ng, P.S., Seankongsuk, P., Harikishore, A., Sarathy, J.P., Saw, W.-G., Lakshmanan, U., Sae-Lao, P., Kalia, N.P., Shin, J., Kalyanasundaram, R., Anbarasu, S., Parthasarathy, K., Pradeep, C.N., Makhija, H., Dröge, P., Poulsen, A., Tan, J.H.L., Pethe, K., Dick, T., Bates, R.W., and Grüber, G.* (2020) Discovery of a novel Mycobacterial F-ATP synthase inhibitor and its potency in combination with diarylquinolines. Angewandte Chemie i.Ed, 132, 13397-13406

  43. Shin, J., Singal, B., Manimekalai, M.S.S., Chen, M.W., Ragunathan, P., and Grüber, G.* (2020) Atomic structure of, and valine binding to the regulatory ACT domain of the Mycobacterium tuberculosis Rel protein. FEBS J. 288, 2377-2397

  44. Wong, C.-F., Lau, A.-M., Harikishore, A., Saw, W.-G., Shin J., Ragunathan, P., Bhushan, S., Ngan, S. F. C., Sze, S. K., Bates, R.W., Dick, T., and Grüber, G.* (2021) A systematic assessment of mycobacterial F1-ATPase subunit ε’s role in latent ATPase hydrolysis. FEBS J. 288, 818-836

  45. Ragunathan, P., Cole, M., Latka, C., Aragaw, W.W., Hegde, P., Shin, J., Manimekalai, M.S.S., Rishikesan, S., Aldrich, C., Dick, T., and Grüber, G.* (2021) Mycobacterium tuberculosis PanD structure-function analysis and identification of a potent pyrazinoic acid-derived enzyme inhibitor. ACS Chem. Biol.16, 1030-1039

  46. Shin, J., Singal, B., Grüber, A., Wong, M.K.D., Ragunathan, P., and Grüber, G.* (2021) Atomic structure of the TGS domain of Rel protein from Mycobacterium tuberculosis and its interaction with deacylated tRNA. FEBS Lett. 595, 3006-3018

  47. Shin, J., Harikishore, A., Wong, C.-F., Ragunathan, P., Dick, T., and Grüber, G.* (2022) Atomic solution structure of Mycobacterium abscessus F-ATP synthase subunit ε and identification of Ep1MabF1 as a targeted inhibitor. FEBS J. in press

  48. Saw, W.-G., Leow, C.Y., Harikishore, A., Shin, J., Cole, M., Aragaw, W.W., Ragunathan, P., Hegde, P., Aldrich, C.C., Dick, T., and Grüber, G.* (2022) Structural and mechanistic insights into Mycobacterium abscessus aspartate decarboxylase PanD and a pyrazinoic acid-derived inhibitor. ACS Infect. Dis., in press

1 (Authors have equal contribution)

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last update 10-Jun-2022